TYR and albinism: Based on the genetic etiology OCA (nonsyndromic) is classified into eight different subtypes (OCA1-7 and OA) [3–5]. The overlapping syndromic albinism such as Hermansky–Pudlak syndrome (HPS), Griscelli syndrome (GS), and Chediak–Higashi syndrome (CHS) have also been reported. Among all, OCA1 is the second most common sub-group of OCA categorized into two types; OCA1A (complete lack of Tyrosinase activity results in the absence of pigmentation in hair, skin, and eyes) and OCA1B (with residual Tyrosinase activity) [6].