Moreover, comparing B-ALL with CBD, the mRNA expression levels of ENSG00000170561 (IRX2), ENSG00000135333 (EPHA7), ENSG00000213934 (HBG1), ENSG00000170549 (IRX1) and ENSG00000102755 (FLT1) were upregulated (Fig. 2C), while ENSG00000169429 (CXCL8), ENSG00000123689 (GOS2), ENSG00000163421 (PROK2), ENSG00000163739 (CXCL1), ENSG00000112715 (VEGFA) in B-ALL were downregulated (Fig. 2D). The gene discussed is HBG1; the disease is precursor B-cell acute lymphoblastic leukemia.