ENO1 and precursor B-cell acute lymphoblastic leukemia: Although another enriched pathway of Glycolysis/Gluconeogenesis did not conform to the threshold of FDR < 0.01, DETs including ENO1, a key enzyme functioning in glycolysis process were enriched in Glycolysis/Gluconeogenesis pathway following the GSEA analysis (NES = -1.553, p = 0.005, FDR = 0.036) (Fig. 4C), which indicated that the pathogenesis of B-ALL were associated with the deregulated expression of glycometabolism-related genes resulting in abnormal energy supply.