When comparing percent genome wide-LOH scores between BRCA1 and BRCA2 mutated tumours in both breast and ovarian cohorts, the scores were higher for BRCA1 than BRCA2 in ovarian (28 vs. 20, P < 0.001), and in breast (25 vs. 22, P < 0.001) (Supplementary Fig. 3). Here, BRCA2 is linked to neoplasm.