In high-grade serous ovarian cancer (the most common subtype), 18–30% of all BRCA mutations are reported to be somatic [7], and when broken down into individual genes, rates of 28 and 26% have been reported for BRCA1 and BRCA2, respectively [5, 7, 34]. The gene discussed is BRCA1; the disease is ovarian serous adenocarcinoma.