BRCA2 and breast neoplasm: Bi-allelic loss of BRCA mutations was seen to be frequent in both germline and somatic mutations, ranging from 81 to 100% for BRCA1 and 92 to 100% for BRCA2 mutations (germline and somatic) for ovarian tumours and 83–96% and 78–80%, respectively in breast tumours (Table 2).