In agreement with the TCGA data, the degree of bi-allelic LoF was high; 96% for BRCA1 (both germline and somatic), 89 and 90% for BRCA2 (germline and somatic, respectively) in ovarian tumours and 86–91% and 75–86%, respectively, in breast tumours. This evidence concerns the gene BRCA2 and breast neoplasm.