Mean age was 59 ± 14.5 years, there were 37 men (46.2%); and the patient population had several very high-risk features, including diabetes 55 (71.4) and hypertension 64 (80%); baseline sCr 2.9 mg/dL (2.3); CKD was present in 34 (44.2%), with an eGFR 28 ml/min/1.73 m2 (31); acute myocardial infarction in 16 (21.3%); chronic heart failure 50 (65.8%); systolic 130 (23) mmHg and diastolic 75 (13) mmHg blood pressure; proteinuria on dipstick 38 (64.4%); and BNP 2631 (1713) ng/dL. This evidence concerns the gene NPPB and Hypertension.