In a post hoc analysis of the 4D Study (Die Deutsche Diabetes Dialyse Studie), Drechsler et.al focused on 1168 dialysis patients with type 2 diabetes mellitus followed for 4 years and found that log-transformed galectin-3 level was associated with CV events defined as a composite of cardiac death in both unadjusted (HR = 1.13, 95% CI 1.03–1.24) and fully adjusted (HR = 1.12, 95% CI 1.01–1.24) models [17]. Here, LGALS3 is linked to diabetes mellitus.