The phenotypes observed in patients with these 7 variants were UPJO, duplex collecting system and renal agenesis for FRAS1 variants, VUR, L-Duplex ureter, PUV and horse-shoe kidney (syndromic) for TNXB variants, VUR for FREM2 variant, PUV for CHD1L gene and VUJO with Duplex system for variant in SIX5 gene. Here, SIX5 is linked to renal agenesis.