Three novel missense variants which were absent in Gnomad were identified in PAX2 (p.Ser305Leu in child with unilateral hypodysplastic kidney), SALL1 (p.Phe447Tyr in patient with bilateral VUR) and RET genes (p.Gly533Ser in child with unilateral vesico-ureteric junction obstruction). Here, PAX2 is linked to medical procedure.