EGFR and hepatocellular carcinoma: Apart from these mechanisms, it have been reported in many previous studies that the action PSPH in cancers are 5-fluorouracil-induced increased accumulation of reactive oxygen species through PSPH-mediated serine synthesis in colorectal cancer [23], inhibition of apoptosis in hepatocellular cancer, promotion of osteoclastogenesis in bone metastatic breast cancer [24] and notably, EGFR amplification in lung adenocarcinoma which was associated with PSPH overexpression [25].