In our current study, although the high glucose level is naturally dropped in KKAy murine model after age of 18 weeks according to the literature (Zhang et al. 2020), we still observed the effects of KD on lowering plasma glucose and improving insulin sensitivity in T2DM mice compared with those of SD, which was consistent with previous publication (Yang et al. 2021). The gene discussed is INS; the disease is type 2 diabetes mellitus.