In contrast, METTL15, zinc finger CCCH-type containing 13 (ZC3H13), fat mass and obesity-associated (FTO), leucine-rich pentatricopeptide repeat containing (LRPPRC), and RNA-binding motif protein 15B (RBM15B) showed widespread CNV frequency loss (Figure 2B). The gene discussed is LRPPRC; the disease is obesity due to melanocortin 4 receptor deficiency.