IGF2 and neoplasm: In addition, Botai et al. demonstrated that circNDUFB2 (a circular RNA) is involved in the degradation of the insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) (an m6A reader) during the progression of non-small cell lung cancer, which in turn activates anti-tumor immunity [20].