NLRP3 and infection: To make the mice susceptible to SARS-CoV-2 infection, they were made to overexpress hACE2 protein, the receptor for SARS-CoV-2 entry, by intranasal infection of adenovirus-associated virus carrying the hACE2 gene (AAV-hACE2) in C57BL/6J wild type and Nlrp3-KO mice.