Simulations were also conducted to evaluate the effect of different dose initiation strategies for aripiprazole AOM, effect of CYP2D6 metabolizer status, effect of coadministration of CYP2D6 and CYP3A4 inhibitors, and effect of missed doses on the AOM PK profile and its position relative to the therapeutic window. Here, CYP3A4 is linked to infectious otitis media.