Here, our results indicated that BCL9 CN gain was associated with the higher performance status, enlarged liver size, higher focal lesion size, and thrombosed portal vein; although this association did not reach the significance, this may lead to that BCL9 CNV might have a role in HCC development, and there was not any significant association between this CN gain and the other parameters. This evidence concerns the gene BCL9 and hepatocellular carcinoma.