An important point was discussed in our results; AFP status was higher in the majority of the BCL9 CN gain group, as AFP is the most common marker for HCC diagnosis [62]; therefore, we speculate that there is a vital role of AFP to be taken into consideration as an influencer with BCL9 CNV in HCC patients, but further work is needed to verify our hypothesis. The gene discussed is BCL9; the disease is hepatocellular carcinoma.