The NIA-AA adopted the proposition of “A/T/N system” in which three categories of AD biomarker (imaging and biofluids) are summarized based on the nature of the pathologies mechanisms: A (biomarkers of β-amyloid, Aβ)/T (biomarkers of fibrillar tau)/N (biomarkers of neurodegeneration or neuronal injury) [7]. Here, MAPT is linked to Alzheimer disease.