Several neurodegenerative diseases are characterized by tau aggregates; however, the tau aggregates vary in those disease either for morphology (e.g., neurofibrillary tangles for AD vs. astrocytic plaques, Pick bodies, or globose tangles in other neurodegenerative tauopathies) or ultrastructural conformations (e.g., paired helical filaments in AD vs. mainly straight or twisted filaments in other neurodegenerative tauopathies) [27]. Here, MAPT is linked to neurodegenerative disease.