PRNP and infection: It is thus conceivable that PrPSc molecules nascently converted from PrPC in N2aC24 cells after IAV/WSN infection might form oligomeric aggregates, or PrPSc seeds, subsequently recruiting other PrPC molecules to them to convert them into PrPSc without the help of IAV/WSN and thereby enabling the constitutive conversion of PrPC into PrPSc in N2aC24R1 cells even after IAV/WSN infection is cleared (Figure 1(a)).