CD47 is located on the surface of cancer cells and interacts with signal-regulatory protein alpha (SIRP-α) to induce tolerance in immune cells, prevent cancer cells phagocytosis, and prolong cancer cells survival in pancreatic cancer.120,121 CD47 blockade enhanced the antitumor function of CD8 + T cells and macrophages in the mice model of pancreatic cancer.122 Likewise, immunotherapy with CD47-CAR-T cells significantly reduced pancreatic cancer cells population and prevent pancreatic cancer growth in mice.123. Here, SIRPA is linked to familial pancreatic carcinoma.