BTYNB, a potent and selective inhibitor of IMP1, significantly decreased the expression of c-Myc and suppressed the proliferation of IMP1-containing ovarian cancer and melanoma cells.190 IMP1 protects the coding region instability sequence of c-Myc mRNA against endonucleolytic cleavage.191 Similarly, IMP1 can bind to KRAS mRNA and regulate its expression. The gene discussed is MYC; the disease is melanoma.