NFATC1 and familial pancreatic carcinoma: ELK1 vigorously increases the transcription of c-Myc and promotes its expression.185 Buchholz et al. revealed that NFATc1 is a major inducer of c-Myc expression, thereby increasing pancreatic cancer cells proliferation.184 Induction of NFAT/c-Myc pathway promoted pancreatic cancer growth and NFAT depletion reduced c-Myc expression and decreased pancreatic cancer growth in vitro and in vivo.184,185 Inhibition of NFAT can be a promising method to suppress the transcription of c-Myc and decrease its oncogenic effects.