Another inhibitor of c-Myc/MAX dimerization, 10,058-F4, could increase apoptosis in pre-B cell ALL cell line and improve cancer cells sensitivity to other drugs such as dexamethasone and vincristine.150,151 The same compound could also improve the sensitivity of acute promyelocytic leukemia (APL) to arsenic trioxide.152 Treatment with 10,058-F4 also reduced pancreatic cancer cells viability by accelerating their apoptosis. The gene discussed is MYC; the disease is acute promyelocytic leukemia.