Inhibition of calcineurin signaling or knockdown of NFAT1c led to G1 arrest and could drastically decrease pancreatic cancer cells proliferation.184,185 NFAT1c binds to serum responsive element in the proximal promoter and prepares local chromatin structure for Ets-like gene 1 (ELK1) activity. The gene discussed is ELK1; the disease is familial pancreatic carcinoma.