HIF1A and neoplasm: C-Myc increases the expression of miR-17-92 and subsequently prevents the expression of Tsp1 and CTGF.49 Interestingly, Chen et al. revealed that c-Myc can post-transcriptionally promote the expression of HIF-1α and potentiate HIF-1α/VEGF axis to improve angiogenesis.50 In response to hypoxia, HIF-1α stimulates VEGF expression and accelerates angiogenesis.51 Targeting c-Myc as a positive regulator of angiogenesis can impair tumor cells’ metabolism and decrease their metastatic potential.