Extracellular signal-regulated kinases (ERK) inhibition leads to growth arrest in KRAS-mutant pancreatic cancer which is partly mediated through c-Myc degradation.93 Additionally, it was shown that lncRNAs can modulate ERK function to regulate c-Myc and pancreatic cancer cells proliferation. Here, MAPK1 is linked to familial pancreatic carcinoma.