IGF2BP1 and familial pancreatic carcinoma: Deletion of IMP1 significantly reduced KRAS expression.192 Consistently, Zhai et al. uncovered that IMP1 binds to and stabilizes c-Myc mRNA in pancreatic cancer, thereby augmenting cancer cells proliferation.94 In addition, impaired function of IMP1 was associated with decreased c-Myc expression and reduced tumor cells proliferation in pancreatic cancer cells.94 Regarding the effect of IMP1 on the stabilization of c-Myc and KRAS mRNA, IMP1 inhibitors are ideal choices to indirectly target both c-Myc and KRAS in pancreatic cancer.