Moreover, it was observed that c-Myc can downregulate PGC-1α which is the major regulator of mitochondria biogenesis and negatively regulates glycolysis and Warburg effect.34–37 Consistently, it was shown that higher KRAS and c-Myc expression are associated with increased glucose uptake among patients with pancreatic cancer. This evidence concerns the gene KRAS and pancreatic neoplasm.