MYC and familial pancreatic carcinoma: sAJM589 could effectively decrease the expression of c-Myc target genes and even decrease the bioavailability of c-Myc in Burkitt lymphoma cell model.149 C-Myc/MAX interaction is necessary for binding to the E-box of target genes and without this heterodimer, c-Myc remains non-functional.149 Mycro3, another inhibitor of c-Myc/MAX dimerization, could significantly promote pancreatic cancer cells apoptosis.66 Mycro3 (up to 100 mg/kg/day for 2 weeks) also lead to a drastic decrease in tumor cells proliferation and shrinkage in tumor size.66