They also repress the transcription of E-cadherin, plakophilin, occludin, and cytokeratin to accelerate EMT of cancer cells.55 Consistently, it was shown that c-Myc increases matrix metallopeptidase (MMP) expression and decreases E-cadherin expression to augment EMT of pancreatic cancer cells.56–58 Increased expression of MMP and decreased expression of cell adhesion molecules can enhance cancer cells’ mobility.59 Therefore, c-Myc can enhance angiogenesis and accelerate EMT to facilitate cancer cells metastasis. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.