MYC and familial pancreatic carcinoma: C-Myc overexpression can strongly enhance pancreatic cancer cells viability against chemotherapy agents.10,61 Meanwhile, c-Myc downregulation or inhibition can improve chemoresistance and increase the efficacy of several chemotherapeutic agents such as nab-paclitaxel and gemcitabine.61–63 Therefore, simultaneous inhibition of c-Myc contributes to overcoming pancreatic cancer chemoresistance.