It has been implicated in tumorigenesis, EMT, and chemoresistance.197 As mentioned, HMGA2 is markedly expressed in pancreatic cancer and higher expression of HMGA2 is associated with lymph node metastasis in pancreatic cancer.198 Regarding these findings, pharmacological attenuation of OLR1 can indirectly inhibit the deleterious effects of c-Myc on pancreatic cancer. Here, HMGA2 is linked to familial pancreatic carcinoma.