LINC00261 decreases c-Myc transcription by methylation of its promoter and inhibits its biologic function.94,127 LINC00346 is another lncRNA that promotes tumorigenesis, pancreatic cancer cells proliferation, migration, and invasion and is negatively associated with overall survival (OS) and disease-free survival in pancreatic cancer. The gene discussed is MYC; the disease is familial pancreatic carcinoma.