MTOR and neoplasm: mTOR controls different molecules such as 4EBP1 and S6 which are crucial for the initiation and elongation phase of ribosomal translation of c-Myc mRNA.172 Furthermore, mTOR regulates the translation of translational factors themselves and many other proteins that their presence is indispensable for tumor cells proliferation.172 PI3K inhibitors, AKT inhibitors, mTOR inhibitors, and combinatorial PI3K/mTOR inhibitors have developed and are passing their clinical trials.173 Perhaps, use of these compounds can improve the management of pancreatic cancer.