Interestingly, c-Myc is involved in the homeostasis and competent function of T regulatory cell which acts as the main player in tumor cells immune-evasion.124,125 Downregulation of c-Myc can impair the immunosuppressive function of T regulatory cells, thereby enhancing the anti-cancer capacity of effector T cells.124 These findings reveal that c-Myc is widely involved in the immune cells-tumor cells cross-talk and downregulation of c-Myc can enormously improve immunotherapy in pancreatic cancer. This evidence concerns the gene MYC and familial pancreatic carcinoma.