C-Myc is a master regulator of tumor cells metabolism which increases glucose consumption in the tumor microenvironment to provide enough energy and produce a sufficient amount of lipids, proteins, and nucleic acids for tumor cells proliferation.39 Interestingly, Sato et al. uncovered that hyperglycemia upregulates c-Myc expression in pancreatic cancer cells and expedites pancreatic cancer growth in mice.40 Here, MYC is linked to Hyperglycemia.