PVT1 and neoplasm: Indeed, LINC00346 binds to CCCTC-binding factor (CTCF), a transcriptional repressor of c-Myc, to increase the transcription of c-Myc.130 LncRNA XLOC_006390 can similarly enhance the biological function of c-Myc by protecting it against ubiquitination and subsequent degradation.131 LncRNA HULC is overexpressed in pancreatic cancer which enhances pancreatic cancer cells proliferation and invasion and augments c-Myc expression.132 Furthermore, P53 can increase the expression of lncRNA Pvt1 to suppress the transcription of c-Myc and prevent tumor growth.133