This effect is known as the Warburg effect or aerobic glycolysis.16 Glycolysis can provide a large amount of lactate that can be used for the anabolic processes of cancer cells.17 C-Myc can enhance pyruvate kinase isoenzyme type M2 (PKM2) expression to improve tumor cell glycolysis.18 Further, c-Myc-induced overexpression of PKM2 was shown to augment tumor cells proliferation, invasion, and chemoresistance.19 Similarly, it was shown that c-Myc, through repression of a lncRNA, IDH1-AS1, can downregulate isocitrate dehydrogenase 1 (IDH1). This evidence concerns the gene PKM and cancer.