MYC and neoplasm: Han et al. developed small molecule c-Myc inhibitors such as MYCi361 and MYCi975 which can directly target c-Myc inside the cells and promote its phosphorylation on threonine-58 and thereby stimulate its ubiquitination and degradation.116 MYCi361 (initially at 50 mg/kg bid for 2 days, then 70 mg/kg/day for 9 days or 55 mg/kg/day, 3 consecutive days a week for 2 weeks) and MYCi975 (50 mg/kg bid for 2 or 3 days) suppressed tumor growth in mice and enhanced intra-tumor immune cells infiltration.