LINC01194 was highly expressed, while miR-655-3p was down-regulated in HCC tissues.miR-655-3p knockdown reversed the effects of si-LINC01194 on the malignant behavior of Huh-7 cells.miR-655-3p was involved in HCC progression through negatively regulating SMAD5. This evidence concerns the gene LINC01194 and hepatocellular carcinoma.