Intriguingly, rs2535629 is located in the intron of ITIH3, a gene that was previously reported to be associated with schizophrenia.[79, 80] In fact, the ITIH3 locus was one of the earliest schizophrenia risk loci identified by GWASs.[79] This risk locus is also one of the best replicated schizophrenia loci in European and Chinese populations.[81] Of note, Brandl et al. The gene discussed is ITIH3; the disease is schizophrenia.