Of note, SFMBT1 copy number abnormality has been identified in patients with brain diseases[68, 69] and a segmental copy number loss of SFMBT1 was identified in idiopathic normal pressure hydrocephalus (iNPH).[70] The main clinical phenotypes of iNPH patients are gait disorder, cognitive impairment, and urinary incontinence.[71] The cerebral structure of iNPH cases also exhibits abnormalities, including enlargement of ventricle, edema of white matter area, and decrease of cerebral blood flow.[72] These results suggest that SFMBT1 may play an important role in the CNS. Here, SFMBT1 is linked to Cognitive impairment.