In conclusion, the present data suggest that repeated intermittent administration of (R)-ketamine during juvenile and adolescent stages could prevent the onset of cognitive deficits and the loss of PV-immunoreactivity in the PrL of mPFC, the decreased spine density in the PrL of mPFC, CA3 and DG of hippocampus from adult offspring after MIA. This evidence concerns the gene PRL and Cognitive impairment.