Repeated intermittent administration of (R)-ketamine during the juvenile and adolescent stages could prevent the development of cognitive deficits, reduced PV-immunoreactivity in the PrL of mPFC and reduced dendritic spine density in the PrL of mPFC, CA3 and DG of the hippocampus of adult offspring after prenatal poly(I:C) exposure. This evidence concerns the gene PRL and Cognitive impairment.