ABCA1 and obesity disorder: Several pharmacological drugs induced ABCB1/Abca1 mRNA309,420,421 and ABCA1 protein,309,391,421 including the anti-obesity drug orlistat,391 the antibiotic sulfoxaflor,420 the leukotriene receptor antagonist zafirlukast,421 as well as the anthracyclines aclarubicin309 and pyrromycin.309 Zafirlukast in particular reduced intracellular cholesterol and lipid content in oxidized LDL-(oxLDL)-induced lipid-overloaded RAW264.7 macrophages, and increased cholesterol efflux from these cells.421