ABCA1 and Alzheimer disease: Bexarotene was used as a standard inducer of ABCA1/Abca1via the RXR pathway in several studies.271,272,280,319,380 Induction of Abca1 mRNA and ABCA1 protein levels was maximal for bexarotene in combination with TO901317.280 Bexarotene is of particular practical relevance as a potential treatment against AD due to its in vivo effects.