The most prominent ABC transporter subfamily involved in AD is the ABCA subfamily of cholesterol and phospholipid transporters, in which particularly ABCA1, ABCA2, ABCA5, and ABCA7 have been associated with AD.28-30,41,43,95,102 For ABCA1,28,41,95,103 and specifically for ABCA7,28,41,95,104-107 genetic variant28,41,108-111 and genome-wide association studies (GWAS)28,41,106,107,112 have suggested that these transporters are risk factors in AD. The gene discussed is ABCA7; the disease is Alzheimer disease.