The HMG-CoA-reductase inhibitors lovastatin and mevastatin resulted in an induction of ABCA6 mRNA in the human endothelial cell line EA.hy926.429 Finally, in an Abca12 pig model of the rare and lethal skin disease Harlequin ichthyosis, it was demonstrated that treatment with the synthetic retinoid acitretin leads to a compensatory induction of Abca6 mRNA.430. Here, ABCA6 is linked to Harlequin ichthyosis.