ABCA1 and Alzheimer disease: In a recent AD GWAS, the rs1800978 polymorphism in the ABCA1 gene was identified as the lead SNP in a new genome-wide significant locus.158 The association of genetic variants of the ABCA1 gene with AD risk was confirmed by exome sequencing data analysis from 32,558 individuals.158 The study identified around 120 variants that have an increased frequency in early-onset AD (EOAD; 1.5%) and late-onset AD (LOAD; 1.1%) cases, compared to 0.5% of all controls.