ABCA3 and leukemia: As discussed above, human leukemia cells exposed to imatinib displayed increased ABCA2 mRNA and ABCA2 protein expression.236 Celecoxib abrogated this effect.236 A similar observation was reported for ABCA3, where the anti-inflammatory drug indomethacin and the ABCA1 inhibitor sirolimus245 (Figure 2) downregulated ABCA3 mRNA in various cancer cell lines.426,449,450 This treatment also resulted in a sensitization of these cell lines toward the TKIs dasatinib, imatinib, and nilotinib when treated with indomethacin.426