RIPK1/3 or MLKL is downregulated in breast cancer,130, 131 colorectal cancer,132, 133, 134 melanoma,135 gastric cancer,136 ovarian cancer,137 head and neck squamous cell carcinoma,138 cervical squamous cell carcimoma,139 and AML.140, 141. The gene discussed is RIPK1; the disease is melanoma.