Based on the promising efficacy, in 2021, the U.S. FDA granted tiragolumab BTD in combination with atezolizumab (Tecentriq) for the first‐line treatment of individuals with metastatic NSCLC whose tumors have PD‐L1 expression ≥50% and no EGFR or ALK genomic tumor aberrations. This evidence concerns the gene CD274 and non-small cell lung carcinoma.