It has been reported that depletion of the HR proteins such as BRCA1/2 in breast cancer cells could stimulate synthetic lethality in PARG‐inhibited cells,167, 168 and that COH34, a PARG inhibitor, is able to induce cell death of ovarian and breast cancers with BRCA mutations or resistance to olaparib.169. This evidence concerns the gene PARG and breast cancer.