For example, in breast cancer, histone methyltransferase nuclear receptor‐binding SET domain 3 (NSD3) cooperates with enhancer of zeste homolog 2 (EZH2) and RNA polymerase II to stimulate the Notch pathway‐mediated E‐cadherin transcriptional inhibition to promote EMT and trigger tumor invasion and metastasis.65 This evidence concerns the gene CDH1 and breast carcinoma.