Specifically, the most well-described variants are patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M (Romeo et al., 2008), transmembrane 6 superfamily member 2 (TM6SF2) E167K (Kozlitina et al., 2014) and obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) (Mancina et al., 2016). The gene discussed is TM6SF2; the disease is obesity due to melanocortin 4 receptor deficiency.