LEP and metabolic syndrome: The leptin to adiponectin ratio (LAR), which has an inversely proportional relationship with adiponectin to leptin ratio, has been shown to correlate with carotid intima-media thickness (Satoh-Asahara et al., 2004) as well as insulin sensitivity (Finucane et al., 2009) and to predict the presence of the metabolic syndrome (Zhuo et al., 2009).