Adiponectin to leptin ratio (LAR) has been mainly studied in the context of obesity-related disorders such as cardiometabolic diseases (Satoh-Asahara et al., 2004), diabetes (Finucane et al., 2009) and metabolic syndrome (Zhuo et al., 2009). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.