In SLE patients, the GG genotype showed a protective effect with respect to develop neuropsychiatric symptoms (P = 0.037, OR = 0.24), leukopenia (P = 0.024, OR = 0.49), and nephritis (P = 0.032, OR = 0.042) but also a higher predisposition to produce anti-SSB autoantibodies (P = 0.027, OR = 2.41). The gene discussed is SSB; the disease is nephritis.