In this study, a meta-analysis of the included 14 groups of data concerning the CDKAL1 rs10946398 locus and T2DM was performed by analyzing allelic models (A vs. C), recessive genetic models (AA+AC vs. CC), and dominant genetic models (AA vs. AC+CC) in T2DM patients and controls. The gene discussed is CDKAL1; the disease is type 2 diabetes mellitus.