One of the most prominent characteristics of severe COVID-19 is the massive release of a wide range of cytokines, such as TNF, interferon γ (IFN-γ) and IL-1, IL-6, and IL-18, which characterizes the cytokine storm observed in SARS-Cov-2 infected patients (56–59, 107, 108). This evidence concerns the gene IL1A and COVID-19.