Of the 66 identified genes, 26 of them were previously associated with AF at the genetic level in the GWAS catalog (https://www.ebi.ac.uk/gwas/) including CASZ1, CAV2, CDKN1A, CEP68, COG5, CPEB4, HCN4, IL6R, KCNH2, KDM1B, LRIG1, MAPT, NEURL, NKX2-5, PHLDB2, PITX2, PPFIA4, PTK2, RPL3L, RPS2, SOX5, SPATS2L, SSPN, SYNE2, SYNPO2L, and TNFSF13. The gene discussed is SOX5; the disease is atrial fibrillation.