LDHA and invasive carcinoma: Like SLC2A1, LDHA was found to increase expression during the transition from precancerous lesions to invasive carcinomas, and multiple studies have confirmed that LDHA is closely related to tumor initiation and progression (Koukourakis et al., 2003; Fantin et al., 2006; Xie et al., 2009; Ooi et al., 2014).