TP53 and neoplasm: GSEA further revealed that several tumor-related hallmarks were enriched in the high-FHPS subgroup, such as MTORC1 signaling, MYC targets V1 and V2, p53 pathway, G2M checkpoint, PIK3-AKT-MTOR signaling, unfolded protein response, glycolysis, and reactive oxygen species pathway (Figure 7D).