PPARGC1A and hepatocellular carcinoma: Moreover, we compared the expression of PPARGC1A and SLC7A11 in HCC tissues of different WHO grade and TNM stage, and the results showed that the protein expression of SLC7A11 was higher in advanced stage and high-grade HCC tissues, while protein expression of PPARGC1A was higher in early stage and low-grade HCC tissues (Supplementary Figure S3).