HACL2 and hepatocellular carcinoma: Univariate COX regression analysis of 10 FHRPGs showed that PPARGC1A, EIF2AK4, UGP2, and ILVBL were protective factors in HCC patients [Hazard Ratio (HR) < 1; p < 0.001] while SLC2A1, LDHA, SLC7A11, STC2, TXNRD1, and STMN1 were risk factors in HCC patients (HR > 1; p < 0.001) (Figure 3A).