In this study, overall survival (OS) analysis showed that core clock genes including DBP, CRY2, PER2, PER3, and RORA were closely related to the prognosis of pan-RCC patients in at least two databases, while DBP and CRY2 have prognostic effects in all three databases, suggesting that they are potential prognostic biomarkers for pan-RCC. This evidence concerns the gene CRY2 and renal cell adenocarcinoma.