Then, immunohistochemistry staining validated from the Human Protein Atlas database revealed that NR1D1 and BHLHE40 protein was increased in renal cancer tissues compared with normal renal tissues, the expression of CRY1 and CLOCK protein was significantly decreased in renal cancer tissues compared with normal kidney tissues (p < 0.05, Figure 4). The gene discussed is CLOCK; the disease is renal carcinoma.