Next, the related rhythm genes CRY2, DBP, PER2, RORA, and PER3 affecting the prognosis of pan-RCC were obtained by survival analysis, and analyzed the prognostic mechanism of five rhythm genes regulating pan-RCC from four aspects: immune infiltration, tumor related pathways, co-expression and drug sensitivity. The gene discussed is CRY2; the disease is renal cell carcinoma.