Since the SDF-1/CXCR4 axis plays an important role in the physiology of HPSCs, we evaluated CXCR4 expression in HSPCs after MM-EV treatment observing an increased surface expression of CXCR4 in MM-EV-treated cells, in both stem/early and late progenitors with a major impact on stem/early progenitors at the higher EV dose (p > 0.05; Figure 5). Here, CXCL12 is linked to Miyoshi myopathy.