To understand the downstream effects of MM-EVs on HPSCs, we examined the fate of specific HSPC subsets following MM-EV exposure using a multiparameter flow cytometer analysis with a combination of antibodies (CD34, CD38, CD45RA, CD10, CD90, and CD123) allowing us to distinguish the classical HSPC subsets (Figure 3A). Here, MME is linked to Miyoshi myopathy.