Whereas earlier studies had identified the Ca2+/phospholipid-binding protein annexin A8 as a LEL-localized component of the machinery facilitating LEL-to-WPB delivery of CD63 (Poeter et al., 2014), Sharda and coworkers (Sharda et al., 2020) recently reported the participation of biogenesis of lysosome related organelle-2 (BLOC-2), a protein that can be mutated in the recessive bleeding disorder Hermansky-Pudlak syndrome. Here, CD63 is linked to Hermansky-Pudlak syndrome.