The physiological and also pathophysiological importance of WPB and their principal cargo VWF is emphasized by the fact that failure to produce and release proper VWF results in von-Willebrand disease, the major inherited bleeding disorder (for reviews see Schneppenheim and Budde, 2011; Leebeek and Eikenboom, 2016). Here, VWF is linked to Von Willebrand disease.