The six SLC genes included SLC15A2, SLC25A34, SLC46A3, SLC16A13, SLC2A1, and SLC26A11. Of these six genes, the expression of SLC25A34, and SLC46A3 was significantly lower in LUAD tissues compared with adjacent normal and lower expression was associated with a poorer prognosis in LUAD patients, suggesting a tumor suppressive effect. Here, SLC46A3 is linked to neoplasm.