Here we performed an integrated analysis of SLC family genes in LUAD by: 1) identifying prognosis-related SLC genes; 2) using them to construct a prognostic signature in LUAD; 3) evaluating the prognostic accuracy of the signature in patients with LUAD; and 4) examining associations between the signature and the tumor immune microenvironment and immune cell infiltration. Here, CCL21 is linked to neoplasm.