GTPase dynamin-related protein 1 (Drp1) is an essential regulator of mitochondrial fission (Fonseca et al., 2019), and Drp1-mediated mitochondrial fission has been reported to contribute to various cardiovascular diseases, such as diabetic cardiomyopathy, ischemia/reperfusion cardiac injury, and DOX-induced cardiomyopathy (Xia et al., 2017; Zhou et al., 2017; Ding et al., 2018; Lee et al., 2020; Zhuang et al., 2021). Here, DNM1L is linked to diabetic cardiomyopathy.