PRKN and cardiomyopathy: Whereafter, in vitro studies further showed the accumulation of PINK1 on the mitochondria and the translocation of Parkin from cytosol to mitochondria, together with the ubiquitination of mitochondrial substrates in DOX-treated H9C2 cells, confirming the activation of PINK1/Parkin signaling pathway-regulated mitophagy in DOX-induced cardiomyopathy.