H19 knockdown exerts a negative effect on the migration and invasion of NSCLC A549 cells by modulating MAPK signaling pathway-related protein ERK1/2 expression and other signaling pathway protein expressions associated with cell proliferation and cell adhesion, such as metastasis-associated in colon cancer 1 (MACC1), EGFR, and β-catenin (Wang et al., 2016). Here, MACC1 is linked to non-small cell lung carcinoma.