Decreased insulin receptor substrate I regulates the PI3K/Akt signaling pathway and NF-kB signaling pathway by decreasing the levels of phosphorylated PI3K, phosphorylated Akt, phosphorylated p65, and phosphorylated IκBα in SW579 and TPC-1 thyroid cancer cells (Wang et al., 2017). Here, AKT1 is linked to thyroid cancer.