By means of both bioinformatic analysis and experimental validation, our research also indicated that TDRKH-AS1, MIR4435-2HG, HSD11B1-AS1, TRG-AS1, and AL451085.3 were likely to play tumor-supportive or tumor-suppressive roles in the development and progression of breast cancer and may be valuable independent prognostic indicators for patients with breast cancer. The gene discussed is HSD11B1; the disease is breast cancer.