TNNT2 and autosomal dominant cerebellar ataxia: The separation of degree of hypertrophy from the risk for SCA was shown clearly in a series of seminal studies done by the Knollmann group in which transgenic mice expressing I79N, F110I, and R278C TNNT2 variants were studied prior to the development of any overt form of hypertrophy (Knollmann et al., 2003; Baudenbacher et al., 2008; Schober et al., 2012; Eschenhagen et al., 2015).