CD8A and neoplasm: Surprisingly, the authors also reported efficient cross-presentation promoted by CAR-Mac transfected with Ad5f35, since in co-cultures with CAR-Mac pre-incubated with NYESO1+ tumor cell lines in an HLA-A201+ restricted context, an increase in NYESO1+CD8+CD69+ activated T lymphocytes and an up-regulation of IFN-gamma secretion was detected.