The great majority of TAMs are derived from blood monocytes due to the chemo attractive milieu from the tumor microenvironment, constituted by a large spectrum of soluble factors that includes M-CSF, CCL2, CCL3, CCL4, CCL5, CCL8, SDF1, VEGF, MIP-1, and MIF (Panni et al., 2013). The gene discussed is CCL2; the disease is neoplasm.