Interestingly, the function of PDE4B is cancer-type dependent, i.e., PDE4B overexpression increases malignancy in diffuse large B-cell lymphoma and non-small cell lung cancer (Smith et al., 2005; He et al., 2017), while its underexpression contributes to prostate cancer progression. The gene discussed is PDE4B; the disease is non-small cell lung carcinoma.