CXCL12 and lung cancer: Qin et al. (2021) reported that CAFs induces EMT and enhances gastric cancer migration and migration via the CXCL12-CXCR4 axis. In lung cancer, CAFs-derived SDF-1 induces EMT via CXCR4/β-catenin/PPARδ signaling (Wang Y. et al., 2021).