Even though large-scale, genome-wide association studies have demonstrated that the IL33, IL1RL1, and IL1RAP genes are associated with a susceptibility to asthma in Europeans (Savenije et al., 2014; El-Husseini et al., 2020), there is still a lack of studies into the association of gene polymorphisms of the IL33/ST2/IL1RAP complex for other population groups. The gene discussed is IL1RL1; the disease is asthma.