The analysis of 10 SNPs and lung function indicators showed that the risk of no improvement in PD20 was significantly higher in children with CT and TT genotypes of rs4742170 in IL33 after treatment (OR = 8.679, 95%CI: 1.029–73.215, p = 0.047), suggesting that asthmatic children with a T allele at rs4742170 had a significantly increased risk of poor response to ICS treatment for airway hyperresponsiveness (Table 8). The gene discussed is IL33; the disease is airway hyperresponsiveness.