TP53 and neoplasm: For example, ferroptosis contributes to the tumor suppressive function of p53, due to the ability of p53 to suppress and stimulate the transcription of SLC7A11 (a subunit of cystine transporter, which suppresses ferroptosis) and glutaminase-2 (which supports ferroptosis via glutaminolysis), respectively (Jiang, Kon et al., 2015; Jennis, Kung et al., 2016).