YAP1 and neoplasm: Intercellular cadherin clustering can signal through the Merlin tumor suppressor to activate intracellular Hippo signaling (Kim, Koh et al., 2011; Meng, Moroishi et al., 2016), which in turn catalyzes the phosphorylation of YAP at serine 127 (Zhao, Wei et al., 2007) by Lats1/2.