In mesothelioma cells, antagonizing the E-cadherin-Merlin-Hippo signaling axis unleashes the activity of the proto-oncogenic transcriptional co-activator YAP to promote ferroptosis through upregulation of multiple ferroptosis modulators, including acyl-CoA synthetase long chain family member 4 (ACSL4) and transferrin receptor (Wu, Minikes et al., 2019). This evidence concerns the gene YAP1 and mesothelioma.