IL18 and hematoma: It is possible that, in these two chronic diseases, the continued release of IL-18 leads to abnormal bone formation (Nozaki et al., 2019), while during bone fracture, an acute condition with an early phase lasting approximately 3 days, pro-inflammatory factors and immune cells in the fractured hematoma tissue promote hBMSC migration and fracture healing (Pountos et al., 2019).