ITGB1 and hepatocellular carcinoma: Remarkably, we observed that, in HCC tumor tissues, five CpG sites within the sequence of ITGB1 promoter region, including cg24317988, cg23837756, cg27238079, and cg27645750, had significantly lower methylation levels than in normal tissues, while higher methylation level was only detected at cg15147545 (Figure 2C).