Moreover, accumulating evidence implicates that ITGB1 is aberrantly expressed in multiple cancer types, including breast cancer, lung cancer, gastric cancer, prostate cancer, pancreatic cancer, colorectal cancer, and laryngeal cancer, and contributes to malignant phenotypes of tumors by mediating cell migration, invasion, survival, and apoptosis (Bogorad et al., 2014; Li et al., 2018; Sun et al., 2018). This evidence concerns the gene ITGB1 and colorectal cancer.