Following the undertaking of myeloablation, it was reported that patients (one with TDT and the other with SCD) obtained autologous CD34+ cells which were modified with CRISPR/Cas9 targeting the same BCL11A enhancer (Frangoul et al., 2021).Later, following the patient’s status, authors noticed that both patients exhibited superior concentrations of allelic replacement in blood and bone marrow and boosts in fetal hemoglobin that supplied pan cellularly, transfusion individuality, and removal of vaso-occlusive episodes (in SCD patients) (Frangoul et al., 2021). This evidence concerns the gene CD34 and Schnyder corneal dystrophy.