To explore the role of CPEB4 in the occurrence and development of renal cancer, we firstly searched the TCGA database and found that the mRNA level of CPEB4 in renal clear cell carcinoma tissues was lower than that in para-carcinoma tissues, and was positively correlated with the overall survival and disease-free survival rates in RCC patients. The gene discussed is CPEB4; the disease is clear cell renal carcinoma.