PRKAA2 and breast cancer: For a previous study, we performed an in-depth investigation of UBE2O and demonstrated that UBE2O could promote BC cell proliferation and epithelial–mesenchymal transformation (EMT) and endow BC cells with cancer stemness properties (CSPs) via the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop (Liu et al., 2020b).