Indeed, the inhibitor 5-chloro-6-[1-(2-iminopyrrolidinyl) methyl] uracil hydrochloride (TPI) is one of the most potent HsTP inhibitors (Ki ∼ 20 nM), capable of inducing considerable reduction in tumor growth in mice (Matsushita et al., 1999). This evidence concerns the gene TRIP10 and neoplasm.