Overexpression and elevated HsTP activity have been detected and measured in plasma of cancer patients and have been associated with invasive and metastatic profiles of various cancer types including bladder, colorectal, ovarian and pancreatic tumors (Pauly et al., 1977; Takebayashi et al., 1996a; Takebayashi et al., 1996b; Reynolds et al., 1994). Here, TRIP10 is linked to cancer.