EVs have attracted the attention of many scientists as a good carrier for treating the diseases, such as Qing Mao has researched that lncRNA KLF3-AS1 in human mesenchymal stem cell-derived EVs ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis (Mao et al., 2019). Here, SIRT1 is linked to myocardial infarction.